BREAst screening Tailored for HEr (BREATHE) is a pilot risk-based screening programme that aims to study the acceptability of risk stratification to aid women in their decision making to attend regular screening. Shifting the paradigm from an age-based risk screening, BREATHE integrates both genetic and non-genetic factors to predict one’s breast cancer risk. Participants who have consented to the study would be required to attend three sessions; recruitment, 1st follow-up session and final follow-up session. With the data and biospecimens donated, participants would receive a tailored breast cancer risk report at 1st follow-up session. The final follow-up session is conducted to evaluate the changes in the screening behaviours of participants, and assess if risk-based screening has improved an individual’s willingness to screen regularly.

Principal Investigator(s) (Emails): Associate Professor Mikael Hartman (mikael_hartman@nuhs.edu.sg)

Primary contact(s) (Emails): –

Website: https://blog.nus.edu.sg/breathe/

Selected Research Outputs: PMID: 35358246

Over the course of 2009 and 2010, Singaporean women were enrolled in GUSTO, from a point in early pregnancy. With the longitudinal cohort study being in its 14th year, mother-child dyads have been extensively phenotyped with continuous collection of data. As the GUSTO children journey through life, we are there every step of the way. The detailed observations and sampling on these mothers and children have been instrumental in discovering features more representative of the local and Asian population that can be used to improve the health and potential of our communities, with an earlier start.

Principal Investigator(s) (Emails): Professor Chong Yap Seng (obgcys@nus.edu.sg) and Professor Johan Eriksson (obgjge@nus.edu.sg)

Primary contact(s) (Emails): Huang Lehui Ann (annhuang@nus.edu.sg) and Vicky Tay (medthkv@nus.edu.sg)

Website: www.gusto.sg

Selected Research Outputs: PMID: 23912809

Repository of healthy volunteers, patients with cardiometabolic and cardiomyopathies. Stored samples include serum and whole blood. All individuals have cardiovascular magnetic resonance imaging.

Principal Investigator(s) (Emails): Professor Calvin Chin (gmsccwl@nus.edu.sg)

Primary contact(s) (Emails): –

Website: –

Selected Research Outputs: –

PHASE is a nationally representative longitudinal survey of older community-dwelling Singapore citizens and permanent residents aged 60 years and above at baseline, with three waves of data about the same participants: in 2009 (wave 1), 2011-12 (wave 2) and 2015 (wave 3). In wave 1, 4,990 participants were interviewed, and data was collected on a range of physical, mental and social health variables along with anthropometric and performance measurements. In wave 2, 3,103 participants were re-interviewed, and in addition to wave 1 measures, data was collected on falls, transfers to/from family members, health insurance, and use of health services and medications. In wave 3, 1,572 participants were interviewed for a 3rd time, with additional data on employment, physical activity, health literacy, medication use and adherence, and physical frailty.

Principal Investigator(s) (Emails): Professor Rahul Malhotra (rahul.malhotra@duke-nus.edu.sg)

Primary contact(s) (Emails): care-datarequest@duke-nus.edu.sg

Website: www.duke-nus.edu.sg/care/research/dataset-codebook

Selected Research Outputs: PMID: 31377801

PIONEER is a nationally-representative and a population-based study investigating the clinical, biological, anthropomorphic, and psychosocial phenotypes of elderly (≥ 60 years) Singaporeans (Malays, Indians and Chinese) to better understand the epidemiology, burden, and complex mechanisms associated with age-related sensory deterioration.

Principal Investigator(s) (Emails): Prof Ecosse Lamoureux (ecosse.lamoureux@duke-nus.edu.sg) and Dr Preeti Gupta (preeti.gupta@seri.com.sg)

Primary contact(s) (Emails): –

Website: –

Selected Research Outputs: PMID: 33269099

Initiated in 1993, the main objective of Singapore Chinese Health Study (SCHS) is to build a stable cohort for long term study of dietary, genetic, and environmental determinants of cancer and other chronic diseases in Singapore. The cohort included Chinese Singaporeans residing in public housing. One of the major strengths of SCHS is its ability to examine potential disease-protective dietary factors that are rarely consumed among the well-studied occidental populations.

Principal Investigator(s) (Emails): Professor Koh Woon Puay (kohwp@nus.edu.sg)

Primary contact(s) (Emails): –

Website: https://www.schs.pitt.edu/

Selected Research Outputs: PMID: 28535164; 29457582; 30165478

The Singapore Cohort Of Risk factors for Myopia (SCORM), the first myopia cohort study launched in Asia and one of the first studies in the world, launched in the year 1999. It has provided rich information on the aetiology, pathological abnormalities, genetic and environmental risk factors for myopia in Singapore children. The SCORM study included a total of 1,979 children aged 7 to 9 years to determine the environmental and genetic risk factors for myopia, ocular biometric changes and pathological abnormalities. The SCORM Children were recruited from three schools in Singapore during the years 1999 and 2001 and were followed up annually until 2006 (1,053 children).

Principal Investigator(s) (Emails): Professor Saw Seang Mei (ephssm@nus.edu.sg)

Primary contact(s) (Emails): –

Website: –

Selected Research Outputs: PMID: 11211020

The Singapore Epidemiology of Eye Diseases (SEED) study aimed to investigate prevalence, incidence, risk factors and impact of Asian eye diseases in the three major racial/ethnic groups (Chinese, Malays, Indians) in Singapore. It used an age-stratified random sample selected from 15 districts approximating Singapore’s socio-economic and demographic structure. SEED has three further follow-ups: 6-year follow-up (SEED-2), 12-year follow-up  (SEED-3) and 20-year follow-up (SEED-4). The detailed phenotyping conducted by SEED highlights ethnic differences in disease prevalence and risk factors, which provides important insights into global eye health.

Principal Investigator(s) (Emails): Professor Cheng Ching-Yu (chingyu.cheng@duke-nus.edu.sg)

Primary contact(s) (Emails): 

Website: https://blog.nus.edu.sg/seed/

Selected Research Outputs: PMID: 33393587; 30529130; 25104651

SG100K is a multi-institutional cohort study in Singapore which aims to recruit 100,000 diverse Chinese, Malay, and Indian participants to identify the social, environmental, lifestyle, and genetic factors associated with diseases prevalent in Singapore. SG100K comprises participants from four cohort studies in Singapore: Health for Life in Singapore (NTU), Singapore Population Health Studies (NUS), Singapore Epidemiology of Eye Diseases (SERI) and SingHeart (NHCS). The study will collect detailed information on health, lifestyle, environment, and physical well-being from 100,000 volunteers. This includes assessment of diet and lifestyle choices through a structured questionnaire, and measurement of waist-hip circumference, blood pressure, physical fitness, lung function, body composition, skeletal health, cardiovascular health, cognitive performance, as well as glucose and cholesterol levels. Key biological samples such as blood, urine and skin tapes are also collected.

Principal Investigator(s) (Emails): Professor John Chambers (john.chambers@ntu.edu.sg)

Primary contact(s) (Emails): –

Website: –

Selected Research Outputs: PMID: 31626772; 34960161; 35361824

SingHeart proposes to study a prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI and CT calcium score), cardiovascular exercise physiology, metabolomics, circulating markers of cardiac injury, genetic analysis stool microbiome and non-mydriatic retinal imaging. These findings will be correlated with adverse clinical outcomes including death, stroke and myocardial infarction. In selected cases, follow-up imaging and biomarker samples will also be obtained. These studies will enable us to begin to address a critical gap in our knowledge as to how best to interpret the very large number of cardiovascular tests done in Singapore and how to better predict outcomes and manage healthcare costs in our local populations.

Principal Investigator(s) (Emails): Professor Yeo Khung Keong (yeo.khung.keong@singhealth.com.sg)

Primary contact(s) (Emails): –

Website: –

Selected Research Outputs: PMID: 31752689

The primary objective of SLAS-YS was to furnish scientific evidence to support policy development and implementation of strategies, programs, and practices related to disability prevention and the promotion of healthy ageing in Singapore. The Singapore Longitudinal Ageing Studies (SLAS) comprised of two cohorts aged 55 and above: SLAS-1 (commenced in 2003) and SLAS-2 (commenced in 2008). The Yishun Study (YS) recruited 542 adults (≥21 years) from Yishun via stratified random sampling. Additional recruitment of older individuals (>75 years) occurred at senior activity centres.

SLAS-1

SLAS-2

YS

Principal Investigator(s) (Emails) for SLAS:  Professor Roger Ho Chun Man (pcmrhcm@nus.edu.sg)

Primary contact(s) (Emails) for SLAS: –

Website for SLAS: –

Selected Research Outputs for SLAS: PMID: 33589714

Principal Investigator(s) (Emails) for YS: Dr Rachel Cheong Chin Yee (cheong.chin.yee@ktph.com.sg)

Primary contact(s) (Emails) for YS: –

Website for YS: –

Selected Research Outputs for YS: PMID: 33589714

Over the course of 2015 and 2017, Singaporean women without fertility issues and intending to get pregnant were enrolled in S-PRESTO. S-PRESTO has the advantage to prospectively assess a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood.

Principal Investigator(s) (Emails): Professor Chong Yap Seng (obgcys@nus.edu.sg) and Professor Johan Eriksson (obgjge@nus.edu.sg)

Primary contact(s) (Emails): Huang Lehui Ann (annhuang@nus.edu.sg) and Vicky Tay (medthkv@nus.edu.sg)

Website: www.gusto.sg

Selected Research Outputs: PMID: 33222050

The Singapore Population Health Studies (SPHS) is a population-based health research initiative that aims to (i) investigate the interactions between lifestyle, physiological, genetic and other omics biomarkers and their impact on health and longevity; (ii) serve as a platform to monitor risk factors in the population and gain insight into determinants of health-related behaviours; and (iii) understand disease aetiology in urban Asian settings, and the development of improved preventive and therapeutic measures for Singapore and other Asian populations. Over a span of 20 years, health, lifestyle, environment, and physical well-being from over 70,000 volunteers across a collection of seven independent cohorts, including (i) three independent phases of the Multi-Ethnic Cohort (MEC1, MEC2 and MEC3), (ii) Diabetic Cohort (DC), (iii) Singapore Health Studies (SH2012, SH2) and (iv) Community Healthy Study (CHS).

Principal Investigator(s) (Emails): Associate Professor Sim Xueling (ephsx@nus.edu.sg)

Primary contact(s) (Emails): SSHSPHDataRequest@nus.edu.sg

Website: https://blog.nus.edu.sg/sphs/

Selected Research Outputs: PMID: 29452397; 32474429; 25884916; 29544448; 34360408; 34476210